vIL10 increases spleen cell count at day 14. Mice were infected as indicated in Figure 4. Data represent four independent experiments with five mice per group. Spleens were harvested on days 10, 14, and 21 p.i. Spleens of five mice were pooled and disrupted, and spleen cells were counted. Spleen-cell-count data for Day 0 represent the average of five spleens from uninfected mice. Bars represent standard error of the mean. Statistical significance by unpaired t-test with Welch’s correction is indicated (*): MHV-68 vs MHV-76 (day 10, P = 0.0106; day 14, P < 0.0001; day 21, P = 0.0005) and 76.IL10 vs MHV-76 (day 14, P < 0.0001).