Skip to main content
Figure 5 | Herpesviridae

Figure 5

From: Cytomegalovirus-induced salivary gland pathology: resistance to kinase inhibitors of the upregulated host cell EGFR/ERK pathway is associated with CMV-dependent stromal overexpression of IL-6 and fibronectin

Figure 5

Western blot analysis of pERK protein expression in mCMV-infected and GEF-treated, mCMV-infected NB + 6 and NB + 12 SMGs. A. NB + 6 SMGs. B. NB + 12 SMGs. There is a significant increase in pERK expression in GEF-treated, mCMV-infected NB + 12 SMGs compared to identically treated NB + 6 SMGs (p<0.01; n = 16). GEF treatment results in a significant decrease in pERK expression in mCMV-infected NB + 6 SMGs compared to untreated SMGs (p<0.01; n = 9), but no difference is seen between mCMV-infected and GEF-treated, mCMV-infected NB + 12 SMGs (p>0.4; n = 9).

Back to article page

Herpesviridae

ISSN: 2042-4280