The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS)

Herpesviridae

Table 3 The relationship between 'focal' areas of HSV-1 antigen and demyelinating lesions in the BST-CB of inbred strains of mice

Mouse strain^a	BST^b on day (PI)	CB^c on day (PI)		# of 'focal' areas^d	# of lesions^e		% of 'focal' areas that co-localize with lesions
			BST	CB	BST	CB	BST	CB
SJL/J	12	15	19.7 ± 1.5	25.5 ± 4.1	18.2 ± 1.0	24.0 ± 3.7	92	94
A/J	6	12	24.8 ± 2.0	93.7 ± 1.1	24.1 ± 1.8	90.6 ± 1.0	97	97
PL/J	6	9	56.7 ± 3.1	163.7 ± 7.4	53.4 ± 2.1	162.4 ± 6.0	94	99

^aThree 10-12 week ♀ mice of each strain were infected with HSV-1 strain 2 via the oral mucosa. 'Focal' areas of viral antigen positive cells and demyelinating lesions were determined in serial sections of the brainstem-cerebellum (BST-CB) by IHC and LFB-CFV counterstain.
^bBoth 'focal' areas of viral antigen and demyelinating lesions were determined in the BST of all three mouse strains. Sections of the BST were obtained on the first day demyelinating lesions appear in that mouse strain [24].
^cBoth 'focal' areas of viral antigen and demyelinating lesions were determined in the CB of all three mouse strains. Sections of the CB were obtained on the first day demyelinating lesions appear in that mouse strain [24].
^dAverage number of 'focal' areas of viral antigen ± SD in the BST and CB of each of three mice. Differences among mouse strains are all statistically significant at P < 0.005.
^eAverage number of demyelinating lesions ± SD among in the BST and CB of each of three mice. Differences among mouse strains are all statistically significant at P < 0.005.