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Table 2 The number and size of 'focal' areas of HSV-1 antigen positive cells in the BST-CB of inbred strains of mice

From: The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS)

Mouse straina BSTb examined for focal' areas on day (PI) CBc examined for 'focal' areas on day (PI) # of 'focal' areas
per sectiond
Size of 'focal' areae (μm)
SJL/J 9 12 0.6 ± 0.7 0.7 ± 0.7 97 ± 8 153 ± 6
A/J 5 9 0.7 ± 0.8 2.6 ± 1.0 156 ± 8 285 ± 9
PL/J 5 6 1.6 ± 1.0 4.6 ± 1.7 207 ± 15 373 ± 21
  1. aThree 10-12 week ♀ mice of each strain were infected with HSV-1 strain 2 via the oral mucosa. 'Focal' areas of viral antigen positive cells were determined in serial sections of the brainstem-cerebellum (BST-CB) by IHC and CFV counterstain.
  2. bSections of the BST were examined on the first day that 'focal' areas appear for each mouse strain.
  3. cSections of the CB were examined on the first day that 'focal' areas appear for each mouse strain.
  4. dAverage number of 'focal' areas of viral antigen ± SD per section. Differences among mouse strains are all statistically significant at P < 0.001 except for the difference between SJL/J and A/J BST which was NS.
  5. eAs a single 'focal' area could be represented in several sections, the greatest diameter for each'focal' area was determined. The average diameter ± SD of the 'focal' areas for the three mouse strains was then calculated. Differences between the three mouse strains are all statistically significant at P < 0.001.