|
Mouse straina
|
BSTb examined for focal' areas on day (PI)
|
CBc examined for 'focal' areas on day (PI)
|
# of 'focal' areas
per sectiond
|
Size of 'focal' areae (μm)
|
|---|
|
SJL/J
|
9
|
12
|
0.6 ± 0.7
|
0.7 ± 0.7
|
97 ± 8
|
153 ± 6
|
|
A/J
|
5
|
9
|
0.7 ± 0.8
|
2.6 ± 1.0
|
156 ± 8
|
285 ± 9
|
|
PL/J
|
5
|
6
|
1.6 ± 1.0
|
4.6 ± 1.7
|
207 ± 15
|
373 ± 21
|
- aThree 10-12 week ♀ mice of each strain were infected with HSV-1 strain 2 via the oral mucosa. 'Focal' areas of viral antigen positive cells were determined in serial sections of the brainstem-cerebellum (BST-CB) by IHC and CFV counterstain.
- bSections of the BST were examined on the first day that 'focal' areas appear for each mouse strain.
- cSections of the CB were examined on the first day that 'focal' areas appear for each mouse strain.
- dAverage number of 'focal' areas of viral antigen ± SD per section. Differences among mouse strains are all statistically significant at P < 0.001 except for the difference between SJL/J and A/J BST which was NS.
- eAs a single 'focal' area could be represented in several sections, the greatest diameter for each'focal' area was determined. The average diameter ± SD of the 'focal' areas for the three mouse strains was then calculated. Differences between the three mouse strains are all statistically significant at P < 0.001.
