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Table 1 The appearance and clearance of HSV-1 antigen positive cells and 'focal' areas of viral antigen positive cells throughout the brains of inbred strains of mice

From: The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS)

Mouse straina Initial appearance of viral
antigen positive
cells throughout the brains
Clearance of viral antigen throughout the brain (days PI)
  RTNBSTb BSTc CBd CRe (days PI)  
BL/6 3 - - - 12
BALB/c 3 3 6 7 18
SJL/J 6 6 7 8 21
A/J 3 3 6 7 21
PL/J 3 3 5 6 21
Mouse strain a ext Initial appearance of 'focal' areas of viral antigen positive cells throughout the brain Clearance of viral antigen throughout the brain (days PI)
  RTNBSTa BSTb CBc CRd (days PI)  
BL/6 - - - - 12
BALB/c 5 - - - 18
SJL/J 9 9 12 15 21
A/J 5 5 9 12 21
PL/J 5 5 6 9 21
  1. aTen-12 week ♀ inbred mice were infected with HSV-1 strain 2 via the oral mucosa. Three mice of each strain were examined every 3 days or as necessary from Day 0 through 30 PI.
  2. bRoots of the trigeminal nerve in the brainstem
  3. cBrainstem
  4. dCerebellum
  5. eCerebral hemispheres