The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS)

Herpesviridae

Table 1 The appearance and clearance of HSV-1 antigen positive cells and 'focal' areas of viral antigen positive cells throughout the brains of inbred strains of mice

Mouse strain^a	Initial appearance of viral antigen positive cells throughout the brains				Clearance of viral antigen throughout the brain (days PI)
	RTNBST^b	BST^c	CB^d	CR^e (days PI)
BL/6	3	-	-	-	12
BALB/c	3	3	6	7	18
SJL/J	6	6	7	8	21
A/J	3	3	6	7	21
PL/J	3	3	5	6	21
Mouse strain ^a ext	Initial appearance of 'focal' areas of viral antigen positive cells throughout the brain				Clearance of viral antigen throughout the brain (days PI)
	RTNBST^a	BST^b	CB^c	CR^d (days PI)
BL/6	-	-	-	-	12
BALB/c	5	-	-	-	18
SJL/J	9	9	12	15	21
A/J	5	5	9	12	21
PL/J	5	5	6	9	21

^aTen-12 week ♀ inbred mice were infected with HSV-1 strain 2 via the oral mucosa. Three mice of each strain were examined every 3 days or as necessary from Day 0 through 30 PI.
^bRoots of the trigeminal nerve in the brainstem
^cBrainstem
^dCerebellum
^eCerebral hemispheres