TY - JOUR AU - Kastrukoff, Lorne F. AU - Lau, Allen S. AU - Thomas, Eva E. PY - 2012 DA - 2012/03/26 TI - The effect of mouse strain on herpes simplex virus type 1 (HSV-1) infection of the central nervous system (CNS) JO - Herpesviridae SP - 4 VL - 3 IS - 1 AB - Mice infected with HSV-1 can develop lethal encephalitis or virus induced CNS demyelination. Multiple factors affect outcome including route of infection, virus and mouse strain. When infected with a sub-lethal dose of HSV-1 strain 2 via the oral mucosa, susceptible SJL/J, A/J, and PL/J mice develop demyelinating lesions throughout the brain. In contrast, lesions are restricted to the brainstem (BST) in moderately resistant BALB/c mice and are absent in resistant BL/6 mice. The reasons for the strain differences are unknown. SN - 2042-4280 UR - https://doi.org/10.1186/2042-4280-3-4 DO - 10.1186/2042-4280-3-4 ID - Kastrukoff2012 ER -