Low levels of Human Cytomegalovirus Infection in Glioblastoma multiforme associates with patient survival; -a case-control study

Table 1 Patients' characteristics

Characteristics	Case control cohorts
	Patients surviving	Patients surviving
	> 18 months (n = 40)	≤ 18 months (n = 40)
	(2000-2005)	(2000-2005)
Age (years)
< 50	12(30%)	9 (23%)
≥ 50	28(70%)	31(77%)
Gender
Male	24(60%)	24(60%)
Female	16(40%)	16(40%)
RPA class
III-IV	28(70%)*	10(25%)*
V-VI	12(30%)	30(75%)
Extent of surgery
Partial	3 (7.5%)	9 (22.5%)
Radical	37(92.5%)#	31(77.5%)#
Gammaknife
No	28(70%)	35(87.5%)
Yes	12(30%)	5 (12.5%)
RT + Temozolomide
No	32(80%)	39(97%)
yes	8 (2%)	1 (3%)
RT + adjuvant chemotherapy
No	17(42%)	21(52%)
Yes	23(58%)	19(48%)
Median follow-up time of those alive at study closure (months)	48 (n = 15)	0 (n = 0)

A significant association was observed between RPA III-VI and number of patients with overall survival > 18 months *: p < .0001. No significant association was observed between radical surgery and longer patients survival #: p .06 (Chi-Square test)