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Table 1 Clinical and laboratory finding of the patients in this study

From: Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 2

  Patient 1 Patient 2 Patient 3
Family history available No Yes No
Age at the time of the study 4 years 21 months 16 months
Age at onset 3 years 17 months 16 month
Fever Yes Yes Yes
Hepatomegaly 4 cm 5 cm 2.5 cm
Splenomegaly 2 cm 3 cm 1 cm
White blood cells (×109/L) 11.6 6.36 3.03
Neutrophils (×109/L) 1.61 3.915 0.56
Hemoglobin (g/dL) 8.1 9.6 7.5
Platelets (×109/L) 95 56 30
LDH (IU/L) 449 1,693 1,698
AST (IU/L) 88 122 453
ALT (IU/L) 31 25 255
Ferritin (μg/L) 1,276 26,282 11,129
sIL-2R (U/mL) 3,162 2,880 14,334
IgG (mg/dL) 1,821 806 423
IgA (mg/dL) 302 124 32
IgM (mg/dL) 1,843 40 18
Whole blood EBV-DNA (copies/mL) 140,000 5,700 1,400,000
  1. LDH, lactate dehydrogenase; AST, aspartate amino transferase; ALT, alanine amino transferase, sIL-2R, soluble interleukin-2 receptor; NA: not available.