Figure 2

Effect of TAK-779 treatment during HSV-1 latency on size and activation of memory CD8⁺ T cell population. HSV-1-infected mice were treated with TAK-779 or PBS at 30, 32 and 34 days post-infection (dpi). TG were excised 36 dpi, dispersed into single cells, stained for CD45, CD8¿, and gB-specific T cell receptor, total CD8⁺ T cells (A) or gB-CD8 (B) per TG are presented. Data represent the means and standard errors for 9 PBS treated and 8 TAK-779 treated mice from 2 independent experiments. (C) Alternatively dispersed TG cells were stained for activation markers, CD69 and granzyme B (GrB). Data shown are the means and standard errors for 4 mice per group. Students t test revealed no statistical difference between the groups.