Figure 3

Animation and reactivation of herpesvirus latency. A. HSV-1. Stress signals (lightning bolt) induce the de novo expression of VP16 and its recruitment into the nucleus (likely via HCF) to activate viral IE gene expression. A productive reactivation event follows. B. HCMV. Signals (lightning bolt) induce CD34+ cell differentiation into a dendritic cell, inducing animation and subsequent reactivation through unknown molecular mechanisms. C. EBV. Activation by antigen stimulation of the B cell receptor (BCR) induces B cell differentiation into a plasma cell, inducing animation and subsequent reactivation through unknown molecular mechanisms.