Epstein-Barr virus genetics: talking about the BAC generation

Herpesviridae

Table 1 List of available EBV BACs.

gene/locus	protein function	reference
wild-type B95.8		[10, 23]
wild-type Akata		[22]
BALF4	virus-cell fusion	[43]
BFLF2	DNA packaging, nuclear egress	[74]
BFRF1	nuclear egress	[75]
BGLF4	protein kinase	[38, 76, 77]
BGLF5	alkaline exonuclease, virus maturation	[78]
BHRF1	anti-apoptotic	[61]
BHRF1+BARF1	anti-apoptotic	[61]
BLLF1	virus binding	[42]
BMRF1	DNA polymerase processivity	[79, 80]
BMRF1+BALF5	DNA replication	[80]
BNRF1	virus transport	[81]
BNLF2a	immune evasion	[37]
BRLF1	lytic replication	[47]
BZLF1	lytic replication	[47]
BZLF1 promoter	lytic replication	[82]
EBNA1	episome maintenance, transactivation	[59]
EBNA2	transformation, transactivation	[83]
EBNA3A conditional EBNA3A	transformation, transactivation	[84] [85]
EBNA3B	unknown	[23]
EBNA3C conditional EBNA3C conditional †	transformation, transactivation	[84] [86]
LMP1	transformation, transactivation	[87]
LMP2A	membrane signal transduction, B cell survival	[88]
oriLyt ZRE sites	lytic replication	[89]
CTCF binding site between oriP and Cp	EBNA2 transcription	[90]
snoRNA1	unknown	[91]
terminal repeats	DNA packaging	[92]