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Figure 4 | Herpesviridae

Figure 4

From: Chromosomal integration of an avian oncogenic herpesvirus reveals telomeric preferences and evidence for lymphoma clonality

Figure 4

MDV-induced lymphomas exhibit a variety of ploidy-level abnormalities. Karyotype abnormalities were common in the tumors and the tetraploid cells typically had double the number of MDV integration sites (green) as compared to diploid cells. As shown here, a tetraploid cell (A) from tumor 12-T1 of Bird 12 had ten MDV integration sites (the majority of diploid cells for 12-T1 had five integration sites). Aneuploid cells (B and C) were also observed in the tumors, in the cell shown in panel B there are three copies of GGA 1 and 2, and two copies of both GGA W and Z. The cell shown in panel C from 12-T1 has several karyotype abnormalities, including four copies of GGA 12 (arrowheads, yellow signals), two of which have MDV on them. The mode of integrations for diploid cells in 12-T1 was five, where as the cell in panel C displays six MDV integration sites with the addition of the tetrasomic GGA 12, indicating non-disjunction occurred after viral integration. GGA 26 (red) is also shown here as having one homolog positive for MDV integration (indicated by superscript text). Scale bar, 5 μm

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