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Table 2 Pyk2 binding partners in pUS28-expressing U373

From: HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase

CATEGORY

PROTEIN(S) IDENTIFIED

Cytoskeleton Structure and Dynamics

β-actin, α1-actin, α2-actin, Nectin-3 [100], Myosin-9, Myosin light chain-6, Tropomyosin-α1 [72, 90, 91]

Signal Transduction

USP6 oncogene* [101], NIM1 kinase* [102], Copine-5* [103], Abl-interactor-2* [104], TFG [54]

Inflammation and Immunity

Immunoglobulin lambda light chain [97], NFκB p105

Cellular Proliferation

TCF-4 [50, 65], AF-17 [98], RTEL-1* [99, 105, 106], N-acetyltransferase-10 [107], Integrator complex subunit 6 [108]

Stress Response

BiP [61, 109], Mortalin [62, 110], Hsc70 [63, 64]

  1. Boldface font indicates proteins identified as Pyk2 associated in multiple cell types
  2. * indicates proteins identified with low abundance (< 3 spectral hits on a single peptide).
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Herpesviridae

ISSN: 2042-4280