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Table 1 Pyk2 binding partners in pUS28-expressing RSMC

From: HCMV pUS28 initiates pro-migratory signaling via activation of Pyk2 kinase

CATEGORY PROTEIN(S) IDENTIFIED
Cytoskeleton Structure and Dynamics β-actin, α1-actin, F-actin capping proteins-α1, -α2*, and -β, Gelsolin [51, 72, 88, 89], Myosin-9, -10, -11, Myosin light chain-6, Tropomodulin-3[72], Tropomyosin-α1, α3, α4 -β [72, 90, 91], Tubulin-β-2C, Vimentin [92]
Signal Transduction Calmodulin [30, 50], G-protein subunit β5 [93], KSR-2* [53, 94], Rhophilin-2* [95], Trio* [52, 96], TFG [54]
Inflammation and Immunity Immunoglobulin lambda light chain [97], NFκB p105
Cellular Proliferation AF-17 [98], RTEL-1* [99]
  1. Boldface font indicates proteins identified as Pyk2-associated in multiple cell types
  2. * indicates proteins identified with low abundance (< 3 spectral hits on a single peptide).